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High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

David S Pisetsky*, Helena Erlandsson-Harris and Ulf Andersson

Arthritis Research & Therapy 2008, 10:209 doi:10.1186/ar2440

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Research article   Open Access

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

Agneta Zickert, Karin Palmblad, Birgitta Sundelin, Sangeeta Chavan, Kevin J Tracey, Annette Bruchfeld, Iva Gunnarsson Arthritis Research & Therapy 2012, 14:R36 (20 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Serum levels of high mobility group box 1 protein (HMGB1) are significantly increased in patients with lupus nephritis and remain raised after the initiation of immunosuppressive therapy, possibly indicating persistent inflammatory activity.

Research article   Open Access

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

Heidi Wähämaa, Hanna Schierbeck, Hulda S Hreggvidsdottir, Karin Palmblad, Anne-Charlotte Aveberger, Ulf Andersson, Helena Harris Arthritis Research & Therapy 2011, 13:R136 (26 August 2011)

Abstract | Full text | PDF | PubMed

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