Table 1 |
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Markers of degradation of cartilage and bone |
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| Tissue |
Molecule |
Marker of degradation |
Designation |
|
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| Cartilage |
Type II collagen |
Pyridinoline |
PYD |
| Type II collagen C-terminal and N-terminal telopeptides |
CTX-II, NTX-II |
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| Type II collagen alpha chain fragments |
Col2-3/4 long, Col2-3/4C short |
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| Aggrecan |
Core protein fragments |
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| Keratan sulfate fragments |
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| Noncollagen and nonaggrecan proteins |
Cartilage oligomeric matrix protein |
COMP |
|
| Bone |
Type I collagen |
Pyridinoline, deoxypyridinolin |
PYD, DPD |
| Type I collagen C-terminal and N-terminal telopeptides |
CTX-I, NTX-I |
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| Noncollagenous proteins |
Bone sialoprotein |
BSP |
|
| Tartrate-resistant acid phosphatase |
TRAP |
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Smolen et al. Arthritis Research & Therapy 2008 10:208 doi:10.1186/ar2418 |
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