Table 1

Comparison of definitions of metabolic syndrome

World Health Organization
National Cholesterol Education Program
International Diabetes Federation

Diabetes or impaired fasting glycemia orimpaired glucose tolerance or insulin resistance (hyperinsulinemic, euglycemic clamp-glucose uptake in lowest 25%)

Central obesity: waist circumference ≥ 94 cm (male) or ≥ 80 cm (female)a, or ≥ 90 cm (male) or ≥ 80 cm (female)b
Plus two or more of the following
Three or more of the following
Plus two or more of the following
Obesity: body mass index >30 or waist-to-hip ratio >0.9 (male) or >0.85 (female)
Central obesity: waist circumference >102 cm (male) or >88 cm (female)
Fasting plasma glucose ≥ 5.6 mmol/L or medication
Dyslipidemia: triglycerides ≥ 1.7 mmol/L or HDL cholesterol <0.9 mmol/L (male) or <1.0 mmol/L (female)
Hypertriglyceridemia: triglycerides ≥ 1.7 mmol/L
Hypertriglyceridemia: triglycerides ≥ 1.7 mmol/L or medication
Hypertension: blood pressure ≥ 140/90 mm Hg
Low HDL cholesterol: <1.0 mmol/L (male)or <1.3 mmol/L (female)
Low HDL cholesterol: <1.0 mmol/L (male) or <1.3 mmol/L (female) or medication
Microalbuminuria: albumin excretion >20 μg/minute
Hypertension: blood pressure ≥ 130/85 mm Hg
Hypertension: blood pressure ≥ 130/85 mm Hg or medication

Fasting plasma glucose ≥ 6.1 mmol/L


aEuropeans, Sub-Saharan Africans, and Eastern Mediterranean and Middle East (Arab) populations; bSouth Asians and Ethnic South and Central Americans. HDL, high-density lipoprotein.

Sidiropoulos et al. Arthritis Research & Therapy 2008 10:207   doi:10.1186/ar2397