|
Deaths reported in human gene therapy trials |
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| Year |
Disease target |
Vector |
Comment |
Death related to gene therapy? |
Ref. |
|
|
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| 1999 |
Ornithine transcarbamylase deficiency |
Adenovirus |
Patient died within 4 days from cytokine storm elicited by infusion of vector |
Yes |
[3] |
| 2002 |
X-linked severe combined immunodeficiency |
Retrovirus |
Leukemia developed, linked to insertion of retrovirus adjacent to the LMO2 oncogene promoter |
Yes |
[5] |
| 2006 |
X-linked chronic granulomatous disease |
Retrovirus |
Loss of transgene expression led to death from underlying disease |
No |
[7] |
| 2007 |
Rheumatoid arthritis |
Adeno-associated virus |
Present article |
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Evans et al. Arthritis Research & Therapy 2008 10:110 doi:10.1186/ar2411 |
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