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Fatty acid amide hydrolase (FAAH) activity in synovial tissue from osteoarthritis (n = 5) and rheumatoid arthritis (n = 4) patients |
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| FAAH activity (pmol/minute/mg protein) |
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| Tissue |
Control |
+ URB597 |
| Osteoarthritis synovium |
2.8 ± 0.46 |
Undetectable |
| Rheumatoid arthritis synovium |
1.6 ± 0.42 |
Undetectable |
| Rat liver |
988 ± 84 |
1.28 ± 0.51 |
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FAAH activity was measured by monitoring the release of [3H]-ethanolamine after incubation of homogenates with [3H]-anandamide. Each sample was processed in three separate experiments. Data are presented as mean ± standard error of the mean. URB597, 3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate. | ||
Richardson et al. Arthritis Research & Therapy 2008 10:R43 doi:10.1186/ar2401 |
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