|
Expression of activation markers, adhesion molecules and chemokine receptors in CD4+CD45RO+ Tck cells |
|||||
| Cell phenotype |
Median MFI (range)/percentage positive (%) index |
Changea |
P |
n |
|
|
|
|||||
| Day 0 |
Day 8 |
||||
|
|
|||||
| CD25 |
8.0 (2–49)/9% |
61 (6–884)/18% |
7.5 |
<0.0001 |
40 |
| CD69 |
5.0 (2–43)/1.1% |
41 (5–552)/26.7% |
8 |
<0.0001 |
41 |
| HLA-DR |
19 (4–130)/9% |
60 (11–238)/15% |
3 |
0.0052 |
15 |
| CD62L |
22 (8–255)/17% |
339 (7–1,040)/58% |
15 |
<0.0001 |
31 |
| CD18 |
107 (9–1,026)/97.5% |
319 (53–2,040)/98.5% |
3 |
0.0085 |
21 |
| CD29 |
85 (6–668)/81% |
152 (14–582)/97% |
2 |
0.0132 |
35 |
| CD49d |
180 (5–634)/73.3% |
465 (13–1,461)/82.3% |
2.6 |
<0.0001 |
42 |
| CCR7 |
12 (4–57)/7.4% |
13 (3–138)/8.6% |
1 |
NS |
42 |
| CXCR4 |
52 (18–494)/29% |
270 (124–896)/86.4% |
5 |
<0.0001 |
21 |
| CXCR3 |
32.3 (9–309)/34.3% |
40.4 (17–129)/34.0% |
1 |
NS |
21 |
| CCR5 |
8.3 (4–28)/2% |
10.7 (4–262)/6% |
1 |
NS |
21 |
|
Statistically significant differences in mean fluorescence intensity (MFI) between day 0 and day 8 values from different experiments were calculated using Wilcoxon rank test. aChange index is calculated with reference to Day 0. CCR, CC chemokine receptor; CXCR, CXC chemokine receptor; HLA, human leucocyte antigen; NS, not significant; Tck, cytokine-activated T. | |||||
Brennan et al. Arthritis Research & Therapy 2008 10:R36 doi:10.1186/ar2390 |
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