Table 4 |
|||||
|
Association of demographic, clinical, and laboratory characteristics and MBL2 genotype expression groups: oligoarthritis |
|||||
|
Characteristic |
MBL genotype expression groups |
Pa |
Pb |
||
|
High (n = 77) |
Medium (n = 48) |
Low (n = 26) |
|||
|
Demographic variables |
|||||
|
Males |
22 (29%) |
10 (21%) |
8 (31%) |
NS |
NS |
|
Age (years) at onset |
6.6 (3.4 to 10.6) |
8.7 (2.6 to 12.1) |
6.6 (2.9 to 12.6) |
NS |
NS |
|
Disease duration (years) at follow up |
14.5 (13.6 to 15.9) |
15.1 (13.2 to 16.1) |
15.3 (14.1 to 16.4) |
NS |
NS |
|
Clinical variables |
NS |
NS |
|||
|
Cumulative affected joints |
3 (2 to 6) |
4 (2 to 6) |
2 (2 to 4) |
NS |
NS |
|
Actively involved joints |
0 (0 to 1) |
0 (0 to 1) |
0 (0 to 0) |
NS |
NS |
|
Affected joints |
1 (0 to 3) |
1 (0 to 2) |
1 (0 to 3) |
NS |
NS |
|
Arthritis severity index |
2 (0 to 6) |
2 (0 to 5) |
1.5 (0 to 5) |
NS |
NS |
|
Physician global assessment |
1 (1 to 2) |
1 (1 to 2) |
1 (1 to 2) |
NS |
NS |
|
Childhood Health Assessment Questionnaire score |
0.0 (0.0 to 0.3) |
0.0 (0.0 to 0.1) |
0.0 (0.0 to 0.4) |
NS |
NS |
|
Patients with uveitis |
12 (16%) |
16 (33%) |
6 (23%) |
NS |
NS |
|
Remission status at follow up |
0.02 |
0.01 |
|||
|
Current remission |
43 (56%) |
26 (54%) |
21 (81%) |
||
|
Active, but previous remission |
27 (35%) |
13 (27%) |
1 (4%) |
||
|
Continuously active |
7 (9%) |
9 (19%) |
4 (15%) |
||
|
Radiographic erosions grade III to IV |
11 (14%) |
8 (17%) |
2 (8%) |
NS |
NS |
|
Laboratory variables |
NS |
NS |
|||
|
Erythrocyte sedimentation rate (mm/hour) |
6 (4 to 11) |
8 (5 to 13) |
5 (4 to 11) |
NS |
NS |
|
C-reactive protein (mg/l) |
5 (1 to 5) |
5 (3 to 6) |
5 (5 to 9) |
<0.01 |
0.01 |
|
Antinuclear antibody positivity |
33 (43%) |
18 (38%) |
11 (42%) |
NS |
NS |
|
IgM-rheumatoid factor positivity |
0 |
0 |
0 |
- |
- |
|
|
|||||
|
Included in this analysis are 151 patients with juvenile oligoarthritis. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). aComparison of the high, medium and low genotype expression groups by means of the two-sided Fisher's exact test and Kruskal-Wallis test. bComparison of the high and medium genotype group versus the low genotype expression group by means of the two-sided Fisher's exact test and Mann-Whitney U-test. NS, not significant. |
|||||
|
Dolman et al. Arthritis Research & Therapy 2008 10:R32 doi:10.1186/ar2386 |
|||||
