Table 4

Multivariate model for cardiovascular morbidity in the QUEST-RA study

Cardiovascular events (all)a hazard ratio (95% CI)

All countries

Countries with high prevalence

Countries with low prevalence


Age

1.04 (1.03–1.06)b

1.05 (1.03–1.07)b

1.04 (1.01–1.06)c

Gender (female)

0.49 (0.36–0.66)b

0.45 (0.31–0.66)b

0.55 (0.32–0.94)c

Rheumatoid factor

0.95 (0.68–1.33)

0.95 (0.64–1.41)

0.90 (0.46–1.73)

Extra-articular disease

1.33 (1.00–1.78)

1.28 (0.92–1.80)

1.60 (0.91–2.84)

Hypertension

1.95 (1.44–2.63)b

1.85 (1.29–2.64)c

2.23 (1.28–3.90)c

Hyperlipidemia

2.41 (1.78–3.27)b

2.16 (1.50–3.10)b

3.24 (1.86–5.65)b

Diabetes

1.34 (0.92–1.96)

1.05 (0.65–1.69)

2.20 (1.18–4.09)c

Ever-smoking

1.56 (1.16–2.12)c

1.46 (1.01–2.11)d

1.88 (1.10–3.22)c

Obesity

1.16 (0.81–1.66)

1.52 (1.01–2.27)d

0.57 (0.25–1.28)

Physical inactivity

0.93 (0.67–1.30)

1.11 (0.75–1.65)

0.61 (0.33–1.10)

Myocardial infarction hazard ratio (95% CI)


All countries

Countries with high prevalence

Countries with low prevalence


Age

1.05 (1.02–1.08)c

1.04 (1.01–1.08)c

1.06 (1.00–1.13)c

Gender (female)

0.46 (0.27–0.80)c

0.55 (0.29–1.06)

0.37 (0.13–1.04)

Rheumatoid factor

0.68 (0.36–1.31)

0.68 (0.31–1.48)

0.82 (0.23–2.91)

Extra-articular disease

2.26 (1.29–3.97)c

2.26 (1.17–4.37)c

2.13 (0.71–6.35)

Hypertension

1.45 (0.83–2.53)

1.10 (0.57–2.15)

2.19 (0.72–6.71)

Hyperlipidemia

3.51 (1.98–6.21)b

3.51 (1.80–6.84)b

4.34 (1.41–13.33)c

Diabetes

1.18 (0.59–2.38)

1.27 (0.56–2.90)

1.01 (0.24–4.29)

Ever-smoking

3.20 (1.74–5.90)b

2.47 (1.22–4.99)c

12.14 (2.50–59.05)c

Obesity

0.74 (0.34–1.62)

0.59 (0.22–1.57)

1.36 (0.37–5.01)

Physical inactivity

0.88 (0.46–1.65)

0.96 (0.45–2.07)

0.87 (0.24–3.12)

Stroke hazard ratio (95% CI)


All countries

Countries with high prevalence

Countries with low prevalence


Age

1.02 (0.99–1.05)

1.03 (1.00–1.06)

0.99 (0.93–1.05)

Gender (female)

0.59 (0.31–1.12)

0.66 (0.31–1.42)

0.37 (0.10–1.39)

Rheumatoid factor

0.95 (0.45–2.00)

0.88 (0.38–2.06)

2.67 (0.40–17.71)

Extra-articular disease

1.41 (0.77–2.58)

1.43 (0.69–2.94)

1.31 (0.40–4.30)

Hypertension

2.81 (1.49–5.30)c

2.95 (1.43–6.11)c

2.37 (0.61–9.20)

Hyperlipidemia

1.18 (0.60–2.31)

0.69 (0.27–1.76)

3.69 (1.16–11.78)c

Diabetes

2.23 (1.12–4.44)d

1.70 (0.71–4.07)

4.63 (1.31–16.40)c

Ever-smoking

1.66 (0.89–3.09)

1.74 (0.82–3.69)

1.31 (0.37–4.63)

Obesity

0.72 (0.31–1.68)

0.77 (0.28–2.08)

0.56 (0.11–2.69)

Physical inactivity

1.01 (0.50–2.03)

1.30 (0.59–2.87)

0.52 (0.13–2.09)


High and low values of each cardiovascular event are based on the median. All variables are included simultaneously in the model, adjusted for country. aMyocardial infarct, angina, coronary heart disease, bypass, or stroke. bP < 0.001. cP < 0.01. dP < 0.05. CI, confidence interval; QUEST-RA, Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis.

Naranjo et al. Arthritis Research & Therapy 2008 10:R30   doi:10.1186/ar2383

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