Table 1 |
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Genetic factors confirmed for or suggestive of association with anticitrulline-peptide antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis |
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|
Factor |
ACPA-positive rheumatoid arthritis |
ACPA-negative rheumatoid arthritis |
|
|
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|
Confirmed |
Human leucocyte antigen shared epitope alleles |
Human leucocyte antigen DR3 |
|
Protein tyrosine phosphatase nonreceptor 22 (PTPN22) |
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|
Complement component 5-TNF receptor-associated factor 1 (C5-TRAF1) |
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|
TNFα-induced protein 3-oligodendrocyte lineage transcription factor 3 (TNFAIP3-OLIG3) |
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|
Suggestive |
Cytotoxic T lymphocyte antigen 4 (CTLA4) |
Interferon regulatory factor 5 (IRF5) |
|
Signal transducer and activator of transcription 4 (STAT4) |
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|
|
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van der Helm-van Mil and Huizinga Arthritis Research & Therapy 2008 10:205 doi:10.1186/ar2384 |
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