 ReviewRecent developments in the immunobiology of rheumatoid arthritisAnna K Andersson  , Ching Li  and Fionula M Brennan Kennedy Institute of Rheumatology, Imperial College Faculty of Medicine, 1 Aspenlea Road, London W6 8LH, UK  author email corresponding author email
Arthritis Research & Therapy 2008,
10:204doi:10.1186/ar2370 Abstract
Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis. | 
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