 EditorialMechanisms of oral tolerance revisitedJun Wang  and Rene EM Toes  Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands  author email corresponding author email
Arthritis Research & Therapy 2008,
10:108doi:10.1186/ar2402 See related research by Park et al., http://arthritis-research.com/content/10/1/R11 Abstract
Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding provides novel input into the mechanisms of oral tolerance that could further facilitate its use for the treatment of autoimmunity and chronic inflammatory reactions. | 
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