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Volume 10 Issue 2
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Comment |
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Rheumatologists, take heart! We may be doing something right
Ronald F van Vollenhoven Arthritis Research & Therapy 2008, 10:105 (7 March 2008)
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Role of interleukin-7 in degenerative and inflammatory joint diseases
Joel AG van Roon, Floris PJG Lafeber Arthritis Research & Therapy 2008, 10:107 (18 April 2008)
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Mechanisms of oral tolerance revisited
Jun Wang, Rene EM Toes Arthritis Research & Therapy 2008, 10:108 (25 April 2008)
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Review |
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Recent developments in the immunobiology of rheumatoid arthritis
Anna K Andersson, Ching Li, Fionula M Brennan Arthritis Research & Therapy 2008, 10:204 (14 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets
Annette HM van der Helm-van Mil, Tom WJ Huizinga Arthritis Research & Therapy 2008, 10:205 (31 March 2008)
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Human Th17 cells
Sergio Romagnani Arthritis Research & Therapy 2008, 10:206 (18 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Research |
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A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
Silje W Syversen, Guro L Goll, Espen A Haavardsholm, Pernille Bøyesen, Tor Lea, Tore K Kvien Arthritis Research & Therapy 2008, 10:R28 (2 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus
Seung-Ki Kwok, June-Yong Lee, Se-Ho Park, Mi-La Cho, So-Youn Min, Sung-Hwan Park, Ho-Youn Kim, Young-Gyu Cho Arthritis Research & Therapy 2008, 10:R29 (6 March 2008)
Abstract | Full text | PDF | PubMed | F1000 Medicine | F1000 Biology
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Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza, Theodore Pincus, the QUEST-RA Group Arthritis Research & Therapy 2008, 10:R30 (6 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs, such as methotrexate, reduces the risk of heart attacks and strokes, data from a study of 4,363 patients across 15 countries shows.
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Mild autonomic dysfunction in primary Sjögren's syndrome: a controlled study
Fin ZJ Cai, Sue Lester, Tim Lu, Helen Keen, Karyn Boundy, Susanna M Proudman, Anne Tonkin, Maureen Rischmueller Arthritis Research & Therapy 2008, 10:R31 (7 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Self-reported symptoms and cardiovascular reflex testing identified mild autonomic nervous dysfunction in patients with primary Sjogren's syndrome, and that pathogenic M3R autoantibodies are strongly implicated in the pathophysiology of the disease.
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Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
Koert M Dolman, Nannette Brouwer, Florine NJ Frakking, Berit Flatø, Paul P Tak, Taco W Kuijpers, Øystein Førre, Anna Smerdel-Ramoya Arthritis Research & Therapy 2008, 10:R32 (11 March 2008)
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Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study
Erik Sundberg, Cecilia Grundtman, Erik af Klint, Johan Lindberg, Sofia Ernestam, Ann-Kristin Ulfgren, Helena Harris, Ulf Andersson Arthritis Research & Therapy 2008, 10:R33 (17 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Medicine | F1000 Biology
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Editor’s summary
Expression of the pro-inflammatory high mobility group box chromosomal protein 1 did not change in any consistent manner over 9 weeks of anti-TNF therapy in nine rheumatoid arthritis patients.
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Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study
Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström, Johan Frostegård Arthritis Research & Therapy 2008, 10:R34 (18 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A gluten-free vegan diet induces potentially atheroprotective and anti-inflammatory changes in rheumatoid arthritis patients, including reduced low density lipoprotein (LDL) and oxidated LDL levels and raised natural antibodies against phosphorylcholine.
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Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs
TT Chowdhury, S Arghandawi, J Brand, OO Akanji, DL Bader, DM Salter, DA Lee Arthritis Research & Therapy 2008, 10:R35 (18 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
Fionula M Brennan, Nicola MG Smith, Sally Owen, Ching Li, Parisa Amjadi, Patricia Green, Anna Andersson, Andrew C Palfreeman, Philippa Hillyer, Andrew Foey, Jonathan T Beech, Marc Feldmann Arthritis Research & Therapy 2008, 10:R36 (19 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
Qian Zhang, Ruolin Guo, Edward M Schwarz, Brendan F Boyce, Lianping Xing Arthritis Research & Therapy 2008, 10:R37 (27 March 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores
R Andrew Moore, Owen A Moore, Sheena Derry, Henry J McQuay Arthritis Research & Therapy 2008, 10:R39 (2 April 2008)
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Analysis of bacterial DNA in synovial tissue of Tunisian patients with reactive and undifferentiated arthritis by broad-range PCR, cloning and sequencing
Mariam Siala, Benoit Jaulhac, Radhouane Gdoura, Jean Sibilia, Hela Fourati, Mohamed Younes, Sofien Baklouti, Naceur Bargaoui, Slaheddine Sellami, Abir Znazen, Cathy Barthel, Elody Collin, Adnane Hammami, Abdelghani Sghir Arthritis Research & Therapy 2008, 10:R40 (14 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
DNA from a wide spectrum of bacterial species, some not previously associated with arthritis, were found in the synovial tissue of reactive arthritis patients by broad-range PCR targeting the 16S rRNA gene.
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Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes
Xinjing Luo, Xiaoxia Zuo, Yaou Zhou, Bing Zhang, Yongzhong Shi, Meidong Liu, Kangkai Wang, D Randy McMillian, Xianzhong Xiao Arthritis Research & Therapy 2008, 10:R41 (14 April 2008)
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Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation
Nathalie Busso, Veronique Chobaz-Péclat, Justin Hamilton, Pieter Spee, Nicolai Wagtmann, Alexander So Arthritis Research & Therapy 2008, 10:R42 (15 April 2008)
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Editor’s summary
Soluble tissue factor induces acute inflammation through a thrombin-dependent pathway and both fibrin deposition and platelet activation are essential steps in this process, according to an animal model of rheumatoid arthritis.
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Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve, Victoria Chapman Arthritis Research & Therapy 2008, 10:R43 (16 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Mucosal administration of α-fodrin inhibits experimental Sjögren's syndrome autoimmunity
Jing He, Jinxia Zhao, Zhanguo Li Arthritis Research & Therapy 2008, 10:R44 (18 April 2008)
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A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis
Allison L Smitten, Teresa A Simon, Marc C Hochberg, Samy Suissa Arthritis Research & Therapy 2008, 10:R45 (23 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease
William EB Johnson, Simon Stephan, Sally Roberts Arthritis Research & Therapy 2008, 10:R46 (23 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha
Greg Parsonage, Andrew Filer, Magdalena Bik, Debbie Hardie, Sian Lax, Katherine Howlett, Leigh D Church, Karim Raza, See-Heng Wong, Emily Trebilcock, Dagmar Scheel-Toellner, Mike Salmon, Janet M Lord, Christopher D Buckley Arthritis Research & Therapy 2008, 10:R47 (23 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Action of fibroblast growth factor-2 on the intervertebral disc
Xin Li, Howard S An, Michael Ellman, Frank Phillips, Eugene J Thonar, Daniel K Park, Ranjith K Udayakumar, Hee-Jeong Im Arthritis Research & Therapy 2008, 10:R48 (24 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors
Martha E Hettema, Dan Zhang, Karina de Leeuw, Ymkje Stienstra, Andries J Smit, Cees GM Kallenberg, Hendrika Bootsma Arthritis Research & Therapy 2008, 10:R49 (25 April 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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