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Volume 10 Issue 2

Comment

Editorial   Free Highly Accessed

Rheumatologists, take heart! We may be doing something right

Ronald F van Vollenhoven Arthritis Research & Therapy 2008, 10:105 (7 March 2008)

Abstract | Full text | PDF | PubMed

Editorial   Free

Role of interleukin-7 in degenerative and inflammatory joint diseases

Joel AG van Roon, Floris PJG Lafeber Arthritis Research & Therapy 2008, 10:107 (18 April 2008)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Mechanisms of oral tolerance revisited

Jun Wang, Rene EM Toes Arthritis Research & Therapy 2008, 10:108 (25 April 2008)

Abstract | Full text | PDF | PubMed

Review

Review   Free Highly Accessed

Recent developments in the immunobiology of rheumatoid arthritis

Anna K Andersson, Ching Li, Fionula M Brennan Arthritis Research & Therapy 2008, 10:204 (14 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free Highly Accessed

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets

Annette HM van der Helm-van Mil, Tom WJ Huizinga Arthritis Research & Therapy 2008, 10:205 (31 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free Highly Accessed

Human Th17 cells

Sergio Romagnani Arthritis Research & Therapy 2008, 10:206 (18 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research

Research article   Open Access Highly Accessed

A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients

Silje W Syversen, Guro L Goll, Espen A Haavardsholm, Pernille Bøyesen, Tor Lea, Tore K Kvien Arthritis Research & Therapy 2008, 10:R28 (2 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus

Seung-Ki Kwok, June-Yong Lee, Se-Ho Park, Mi-La Cho, So-Youn Min, Sung-Hwan Park, Ho-Youn Kim, Young-Gyu Cho Arthritis Research & Therapy 2008, 10:R29 (6 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000

Research article   Open Access Highly Accessed

Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study

Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza, Theodore Pincus, the QUEST-RA Group Arthritis Research & Therapy 2008, 10:R30 (6 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs, such as methotrexate, reduces the risk of heart attacks and strokes, data from a study of 4,363 patients across 15 countries shows.

Research article   Open Access Highly Accessed

Mild autonomic dysfunction in primary Sjögren's syndrome: a controlled study

Fin ZJ Cai, Sue Lester, Tim Lu, Helen Keen, Karyn Boundy, Susanna M Proudman, Anne Tonkin, Maureen Rischmueller Arthritis Research & Therapy 2008, 10:R31 (7 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Self-reported symptoms and cardiovascular reflex testing identified mild autonomic nervous dysfunction in patients with primary Sjogren's syndrome, and that pathogenic M3R autoantibodies are strongly implicated in the pathophysiology of the disease.

Research article   Open Access Highly Accessed

Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

Koert M Dolman, Nannette Brouwer, Florine NJ Frakking, Berit Flatø, Paul P Tak, Taco W Kuijpers, Øystein Førre, Anna Smerdel-Ramoya Arthritis Research & Therapy 2008, 10:R32 (11 March 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

Erik Sundberg, Cecilia Grundtman, Erik af Klint, Johan Lindberg, Sofia Ernestam, Ann-Kristin Ulfgren, Helena Harris, Ulf Andersson Arthritis Research & Therapy 2008, 10:R33 (17 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

Expression of the pro-inflammatory high mobility group box chromosomal protein 1 did not change in any consistent manner over 9 weeks of anti-TNF therapy in nine rheumatoid arthritis patients.

Research article   Open Access Highly Accessed

Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study

Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström, Johan Frostegård Arthritis Research & Therapy 2008, 10:R34 (18 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A gluten-free vegan diet induces potentially atheroprotective and anti-inflammatory changes in rheumatoid arthritis patients, including reduced low density lipoprotein (LDL) and oxidated LDL levels and raised natural antibodies against phosphorylcholine.

Research article   Open Access Highly Accessed

Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs

TT Chowdhury, S Arghandawi, J Brand, OO Akanji, DL Bader, DM Salter, DA Lee Arthritis Research & Therapy 2008, 10:R35 (18 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function

Fionula M Brennan, Nicola MG Smith, Sally Owen, Ching Li, Parisa Amjadi, Patricia Green, Anna Andersson, Andrew C Palfreeman, Philippa Hillyer, Andrew Foey, Jonathan T Beech, Marc Feldmann Arthritis Research & Therapy 2008, 10:R36 (19 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood

Qian Zhang, Ruolin Guo, Edward M Schwarz, Brendan F Boyce, Lianping Xing Arthritis Research & Therapy 2008, 10:R37 (27 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores

R Andrew Moore, Owen A Moore, Sheena Derry, Henry J McQuay Arthritis Research & Therapy 2008, 10:R39 (2 April 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Analysis of bacterial DNA in synovial tissue of Tunisian patients with reactive and undifferentiated arthritis by broad-range PCR, cloning and sequencing

Mariam Siala, Benoit Jaulhac, Radhouane Gdoura, Jean Sibilia, Hela Fourati, Mohamed Younes, Sofien Baklouti, Naceur Bargaoui, Slaheddine Sellami, Abir Znazen, Cathy Barthel, Elody Collin, Adnane Hammami, Abdelghani Sghir Arthritis Research & Therapy 2008, 10:R40 (14 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

DNA from a wide spectrum of bacterial species, some not previously associated with arthritis, were found in the synovial tissue of reactive arthritis patients by broad-range PCR targeting the 16S rRNA gene.

Research article   Open Access

Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes

Xinjing Luo, Xiaoxia Zuo, Yaou Zhou, Bing Zhang, Yongzhong Shi, Meidong Liu, Kangkai Wang, D Randy McMillian, Xianzhong Xiao Arthritis Research & Therapy 2008, 10:R41 (14 April 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation

Nathalie Busso, Veronique Chobaz-Péclat, Justin Hamilton, Pieter Spee, Nicolai Wagtmann, Alexander So Arthritis Research & Therapy 2008, 10:R42 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Soluble tissue factor induces acute inflammation through a thrombin-dependent pathway and both fibrin deposition and platelet activation are essential steps in this process, according to an animal model of rheumatoid arthritis.

Research article   Open Access Highly Accessed

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve, Victoria Chapman Arthritis Research & Therapy 2008, 10:R43 (16 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Mucosal administration of α-fodrin inhibits experimental Sjögren's syndrome autoimmunity

Jing He, Jinxia Zhao, Zhanguo Li Arthritis Research & Therapy 2008, 10:R44 (18 April 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis

Allison L Smitten, Teresa A Simon, Marc C Hochberg, Samy Suissa Arthritis Research & Therapy 2008, 10:R45 (23 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease

William EB Johnson, Simon Stephan, Sally Roberts Arthritis Research & Therapy 2008, 10:R46 (23 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

Greg Parsonage, Andrew Filer, Magdalena Bik, Debbie Hardie, Sian Lax, Katherine Howlett, Leigh D Church, Karim Raza, See-Heng Wong, Emily Trebilcock, Dagmar Scheel-Toellner, Mike Salmon, Janet M Lord, Christopher D Buckley Arthritis Research & Therapy 2008, 10:R47 (23 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Action of fibroblast growth factor-2 on the intervertebral disc

Xin Li, Howard S An, Michael Ellman, Frank Phillips, Eugene J Thonar, Daniel K Park, Ranjith K Udayakumar, Hee-Jeong Im Arthritis Research & Therapy 2008, 10:R48 (24 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors

Martha E Hettema, Dan Zhang, Karina de Leeuw, Ymkje Stienstra, Andries J Smit, Cees GM Kallenberg, Hendrika Bootsma Arthritis Research & Therapy 2008, 10:R49 (25 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central


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