Modulation of disease severity by rosiglitazone and pioglitazone treatment during adjuvant-induced arthritis. Animals were treated daily with rosiglitazone (ROSI) 10 mg/kg (n = 8) or pioglitazone (PIO) 30 mg/kg (n = 8) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (n = 7) and normal controls (n = 7) were given 0.5% carboxymethylcellulose alone. Arthritis score (a) and paw oedema (b) were assessed three times a week after onset of arthritis. For paw volume, each data point represents the mean of both hind paws. Data are expressed as means ± SEM. *, P < 0.05 compared with normal controls; #, P < 0.05 compared with AIA controls (Mann–Whitney U test (arthritis score) or ANOVA and Fisher's PLSD post-hoc test (oedema)). Dn, day n.
Koufany et al. Arthritis Research & Therapy 2008 10:R6 doi:10.1186/ar2354