Modulation of body weight gain by rosiglitazone and pioglitazone in the course of adjuvant-induced arthritis. Male Lewis rats were sensitized subcutaneously on the basis of the tail with a single injection of 1 mg of M. tuberculosis. Animals were treated daily with 3 mg/kg (n = 6) or 10 mg/kg (n = 12) of rosiglitazone (ROSI) or 3 mg/kg (n = 6), 10 mg/kg (n = 6) or 30 mg/kg (n = 12) of pioglitazone (PIO) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (n = 11) and normal controls (n = 10) were given 0.5% carboxymethylcellulose alone. Data are expressed as means ± SEM. *, P < 0.05 compared with normal controls; #, P < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD post-hoc test). Dn, day n.
Koufany et al. Arthritis Research & Therapy 2008 10:R6 doi:10.1186/ar2354