Effect of spironolactone on autoantibody levels. At 36 weeks of age, there were significant differences in (a) anti-single-stranded DNA (ssDNA) and (b) anti-double-stranded DNA (dsDNA) antibody levels between control mice and mice treated with 25 mg/kg per day spironolactone. Results represent the mean ± standard error in six to eight mice/group. *P = 0.02, **P = 0.05.
Monrad et al. Arthritis Research & Therapy 2008 10:R5 doi:10.1186/ar2353