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Carrier frequency comparisons of the different HLA-DRB1 allele groups between rheumatoid arthritis cases and controls in Caucasoid and non-Caucasoid population samples |
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| RA cases, n (%) |
Controls, n (%) |
OR (95% CI) |
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| S1 alleles |
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| Caucasoids |
125 (29.4%) |
183 (41.3%) |
0.59 (0.45–0.79) |
| Non-Caucasoids |
87 (26%) |
140 (40%) |
0.52 (0.37–0.71) |
| S2 alleles |
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| Caucasoids |
133 (31%) |
66 (15%) |
2.61 (1.87–3.64) |
| Non-Caucasoids |
48 (14%) |
37 (11%) |
1.40 (0.88–2.21) |
| S3D alleles |
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| Caucasoids |
123 (29%) |
159 (36%) |
0.73 (0.55–0.97) |
| Non-Caucasoids |
112 (33%) |
120 (35%) |
0.95 (0.69–1.30) |
| S3P alleles |
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| Caucasoids |
159 (37.5%) |
108 (24%) |
1.86 (1.39–2.49) |
| Non-Caucasoids |
170 (51%) |
90 (26%) |
2.93 (2.12–4.04) |
| X alleles |
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| Caucasoids |
201 (47%) |
244 (55%) |
0.74 (0.56–0.96) |
| Non-Caucasoids |
145 (43%) |
192 (55%) |
0.61 (0.45–0.83) |
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The Caucasoid sample population refers to the combination of the following population samples: Greek, Spanish, Russian, and American (Whites). The non-Caucasoid sample population refers to the combination of the following population samples: North American (Amerinds), North American (Blacks), Bushmen, Korean, Chinese, and Javanese. The combined odds ratios (ORs) and 95% confidence intervals (CIs) evaluate the significance of the global effect of the different HLA-DRB1 allele groups on rheumatoid arthritis (RA) susceptibility in Caucasoids and non-Caucasoids. | |||
Barnetche et al. Arthritis Research & Therapy 2008 10:R26 doi:10.1186/ar2379 |
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