Table 2

Carrier frequency comparisons of the different HLA-DRB1 allele groups between rheumatoid arthritis cases and controls in Caucasoid and non-Caucasoid population samples

RA cases, n (%)

Controls, n (%)

OR (95% CI)


S1 alleles

Caucasoids

125 (29.4%)

183 (41.3%)

0.59 (0.45–0.79)

Non-Caucasoids

87 (26%)

140 (40%)

0.52 (0.37–0.71)

S2 alleles

Caucasoids

133 (31%)

66 (15%)

2.61 (1.87–3.64)

Non-Caucasoids

48 (14%)

37 (11%)

1.40 (0.88–2.21)

S3D alleles

Caucasoids

123 (29%)

159 (36%)

0.73 (0.55–0.97)

Non-Caucasoids

112 (33%)

120 (35%)

0.95 (0.69–1.30)

S3P alleles

Caucasoids

159 (37.5%)

108 (24%)

1.86 (1.39–2.49)

Non-Caucasoids

170 (51%)

90 (26%)

2.93 (2.12–4.04)

X alleles

Caucasoids

201 (47%)

244 (55%)

0.74 (0.56–0.96)

Non-Caucasoids

145 (43%)

192 (55%)

0.61 (0.45–0.83)


The Caucasoid sample population refers to the combination of the following population samples: Greek, Spanish, Russian, and American (Whites). The non-Caucasoid sample population refers to the combination of the following population samples: North American (Amerinds), North American (Blacks), Bushmen, Korean, Chinese, and Javanese. The combined odds ratios (ORs) and 95% confidence intervals (CIs) evaluate the significance of the global effect of the different HLA-DRB1 allele groups on rheumatoid arthritis (RA) susceptibility in Caucasoids and non-Caucasoids.

Barnetche et al. Arthritis Research & Therapy 2008 10:R26   doi:10.1186/ar2379

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