Table 5

Frequency of IL-6 G-G diplotypes (G-597A; G-174C) by DIP OA status (n = 528 to 530)

Condition

Diplotypes

Condition absent

Condition present

Odds ratio (95% confidence interval)

n

Percentage

n

Percentage

Crude

Adjusted


DIP OA

Total n

306

222

other/other

105

34.3

64

28.8

1.00

1.00

G-G/other

147

48.0

109

49.1

1.22 (0.82–1.81)

1.27 (0.83–1.95)

G-G/G-G

54

17.6

49

22.1

1.49 (0.91–2.44)

1.42 (0.84–2.41)

G-G carriage

192

62.1

150

67.0

1.29 (0.89–1.87)

1.31 (0.88–1.96)

G-G frequency

237

39.9

207

44.8

1.22 (0.96–1.56)

1.19 (0.92–1.55)

Symmetrical DIP OA

Total n

325

204

other/other

114

35.1

55

27.0

1.00

1.00

G-G/other

155

47.7

102

50.0

1.36 (0.91–2.05)

1.45 (0.94–2.23)

G-G/G-G

56

17.2

47

23.0

1.74 (1.05–2.88)

1.69 (0.99–2.87)

G-G carriage

302

62.0

42

87.5

1.46 (1.00–2.15)

1.52 (1.01–2.28)

G-G frequency

267

41.1

196

48.0

1.33 (1.03–1.70)

1.31 (1.01–1.71)

Symptomatic DIP OA

Total n

483

47

other/other

163

33.7

6

12.8

1.00

1.00

G-G/other

230

47.6

28

59.6

3.31 (1.34–8.17)a

3.62 (1.43–9.15)a

G-G/G-G

90

18.8

13

27.7

3.92 (1.44–10.68)a

3.79 (1.35–10.61)a

G-G carriage

302

62.0

42

87.5

3.48 (1.45–8.37)a

3.67 (1.50–9.00)a

G-G frequency

410

42.4

54

57.4

1.83 (1.19–2.81)a

1.62 (1.07–2.45)


Distal interphalangeal osteoarthritis (DIP OA) was defined by the presence of radiographic findings of grade 2 or more in at least two DIP joints. Symmetrical DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of the DIP joints. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.

aP value remained statistically significant after correcting for multiple testing.

Kämäräinen et al. Arthritis Research & Therapy 2008 10:R21   doi:10.1186/ar2374

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