Table 3

Frequency of the IL-6 (G-174C, G-572C, G-597A) genotypes, by DIP OA status

Genotype

Symptomatic DIP OA

P^c

Condition absent (n = 485)

Condition present (n = 47–48)

n

Percentage

n

Percentage

IL-6(G-174C)^a

0.016

GG

93

19.2

13

27.1

GC

235

48.5

29

60.4

CC

157

32.4

6

12.5

G allele carriage

328

67.6

42

87.5

0.004

G allele frequency

421

43.4

55

57.3

0.010^d

IL-6(G-572C)^b

0.362

GG

451

93.0

42

89.4

GC

34

7.0

5

10.6

C allele carriage

34

7.0

5

10.6

0.362

C allele frequency

34

3.5

5

5.3

0.382

IL-6(G-597A)^a

0.023

GG

103

21.2

14

29.8

GA

226

47.0

27

57.4

AA

154

31.8

6

12.8

G allele carriage

331

68.2

41

87.2

0.007

G allele frequency

432

44.5

55

58.5

0.012^e

DIP OA, distal interphalangeal osteoarthritis. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.

^aGenotypes were available for 533 subjects; ^bGenotypes were available for 532 subjects. ^cP value is given for the comparison between DIP OA status groups (Chi-square test or Fisher's exact probability test); ^dP_corr = 0.02, odds ratio 1.75 (95% confidence interval 1.15 to 2.67); ^eP_corr = 0.024, odds ratio 1.76 (95% confidence interval 1.15 to 2.69).

Kämäräinen et al. Arthritis Research & Therapy 2008 10:R21   doi:10.1186/ar2374