Table 1 |
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|
Linkage disequilibrium measures between the studied IL-6 promoter single nucleotide polymorphisms |
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|
Measure |
rs1800797 and rs1800796 |
rs1800797 and rs1800795 |
rs1800796 and rs1800795 |
|
|
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|
D' |
1.0 (0.78–1.0) |
0.968 (0.94–0.99) |
1.0 (0.78–1.0) |
|
LOD |
7.53 |
184.12 |
7.79 |
|
r2 |
0.045 |
0.885 |
0.048 |
|
Haplotypes |
AG 54.0% |
AC 53.3% |
GC 55.5% |
|
GC 3.7% |
GC 2.2% |
CG 3.7% |
|
|
GG 42.3% |
GG 43.8% |
GG 40.8% |
|
|
AG 0.7% |
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|
|
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|
D' – statistical measure of linkage disequilibrium (D' = 1 is known as complete linkage). The numbers in parentheses indicate 95% confidence intervals for D'. The lod score (LOD) serves as a test of the null hypothesis of free recombination versus the alternative hypothesis of linkage. LOD >3 is traditionally regarded as evidence for linkage. r2 is a correlation coefficient between pairs of loci. |
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Kämäräinen et al. Arthritis Research & Therapy 2008 10:R21 doi:10.1186/ar2374 |
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