Table 1

Linkage disequilibrium measures between the studied IL-6 promoter single nucleotide polymorphisms

Measure

rs1800797 and rs1800796

rs1800797 and rs1800795

rs1800796 and rs1800795


D'

1.0 (0.78–1.0)

0.968 (0.94–0.99)

1.0 (0.78–1.0)

LOD

7.53

184.12

7.79

r2

0.045

0.885

0.048

Haplotypes

AG 54.0%

AC 53.3%

GC 55.5%

GC 3.7%

GC 2.2%

CG 3.7%

GG 42.3%

GG 43.8%

GG 40.8%

AG 0.7%


D' – statistical measure of linkage disequilibrium (D' = 1 is known as complete linkage). The numbers in parentheses indicate 95% confidence intervals for D'. The lod score (LOD) serves as a test of the null hypothesis of free recombination versus the alternative hypothesis of linkage. LOD >3 is traditionally regarded as evidence for linkage.

r2 is a correlation coefficient between pairs of loci.

Kämäräinen et al. Arthritis Research & Therapy 2008 10:R21   doi:10.1186/ar2374

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