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Open Access Highly Accessed Research article

Rheumatic Diseases in China

Qing Yu Zeng1*, Ren Chen2, John Darmawan3, Zheng Yu Xiao1, Su Biao Chen1, Richard Wigley4, Shun Le Chen5 and Nai Zheng Zhang6

Author Affiliations

1 Department of Rheumatology, the 1st Affiliated Hospital, Shantou University Medical College, 22 Xinling Road, Shantou, 515041 Guangdong, China

2 Chenghai Municipal Hospital, Huancheng Bei Road, Chenghai District, Shantou, 515800 Guangdong, China

3 World Health Organization Collaborating Center, Community-based Epidemiology, Treatment, and Prevention of Rheumatic Disease, Indonesian Rheumatic Center, 7 Jalan Seroja Dalam, Jakarta-Semarang, 50136 Indonesia

4 World Health Organization Collaborating Center, Epidemiology of Rheumatic Disease, Research Laboratory, Palmerston North Hospital, 240 Park Road, Palmerston North, New Zealand

5 Department of Rheumatology, Renji Hospital, Medical Science of Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001 China

6 Department of Rheumatology, Peking Union Medical College Hospital, 1 Shuaifuyuan, Beijing, 100730 China

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Arthritis Research & Therapy 2008, 10:R17  doi:10.1186/ar2368


See related editorial by Felson, http://arthritis-research.com/content/10/1/106

The electronic version of this article is the complete one and can be found online at: http://arthritis-research.com/content/10/1/R17


Received:16 May 2007
Revisions received:6 November 2007
Accepted:31 January 2008
Published:31 January 2008

© 2008 Zeng et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction

Epidemiological studies of rheumatic diseases have been conducted during the past 20 years in China. The aim of this study was to clarify prevalence rates of common rheumatic diseases in China.

Methods

Relevant reports of population-based surveys conducted from 1980 to 2006 were retrieved. Studies using the World Health Organization-International League of Associations for Rheumatology COPCORD (Community Oriented Program for Control of Rheumatic Diseases) protocol and those that did not employ this protocol but were published in recognized journals were identified and analyzed.

Results

Thirty-eight surveys including 241,169 adults from 25 provinces/cities were pooled for analysis. The prevalence of rheumatic complaints ranged from 11.6% to 46.4%, varying by locality, study protocol and age of the people surveyed. Prevalence of symptomatic osteoarthritis (OA) varied from 5.1% to 20.8%, with common sites of involvement being the lumbar spine, knee joint and cervical spine. Compared with rates of radiographic and symptomatic knee OA in the USA, elderly men in Beijing exhibited similar prevalence rates and elderly women exhibited a higher prevalence. The prevalence of hip OA and hand OA was much lower in Chinese than in Caucasian populations, but both kinds of OA were more common in coal miners. The prevalence of ankylosing spondylitis ranged from 0.2% to 0.54% among Han ethnic Chinese and were lower among mixed ethnic populations. The prevalence of psoriatic arthritis ranged from 0.01% to 0.1%, and that of reactive arthritis was 0.02%; undifferentiated spondyloarthropathy was identified in 0.64% to 1.2% of the individuals included in the surveys. The prevalence of rheumatoid arthritis (RA) ranged from 0.2% to 0.93%, with the highest rate being reported from a Taiwan urban area. In mainland China there were no significant differences in prevalence of RA between the northern and southern parts of China, or between different ethnic groups. The prevalence of hyperuricemia increased after the 1980s. The prevalence of gout was found to have increased in recent decades from 0.15% to 1.98%, apart from in the Taiwan aborigines, among whom the highest prevalence rate of 11.7% was recorded. The prevalence of primary Sjögren's syndrome in Beijing was 0.77% by the Copenhagen criteria and 0.33% by the San Diego criteria. The prevalence of soft tissue rheumatism was 2.5% to 5.7%. Fibromyalgia was seldom observed in China.

Conclusion

Rheumatic diseases are common in China. The prevalence of rheumatic complaints varied with the locality surveyed. The prevalence of OA is comparable with that in Western countries but varies in terms of joint involvement. The prevalence of ankylosing spondylitis is similar to that in Caucasians. Except in Taiwan, the prevalence of RA in China is lower than that in developed countries. The prevalence of hyperuricemia and gout increased after the 1980s, but it remains lower than that in developed countries. More studies are required to evaluate prevalence rates among minority groups in the west and northwest parts of China, and further study is needed to address fibromyalgia in China.

Introduction

Rheumatology is a relatively new subspecialty of medicine in China. The first rheumatology unit in China was established in 1980 in the Peking Union Medical College Hospital. Before that, little was known about the epidemiology of rheumatic diseases in China.

Initiated by International League of Associations for Rheumatology (ILAR) and its then president Professor EP Engleman, and the president of the Chinese Association of Rheumatology, Professor NZ Zhang, a collaborative study of the epidemiology of rheumatic diseases in China was began in 1984 [1,2]. Subsequently, the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) program was proposed by the World Health Organization (WHO), ILAR and the Asia Pacific League of Associations for Rheumatology (APLAR) [3], and many other surveys were conducted either in cooperation with developed countries such as the USA [4] or by Chinese experts alone. This report reviews the epidemiology of rheumatic disease in China.

Materials and methods

Reports of population studies relating to the epidemiology of rheumatic diseases from 1980 to 2006 were screened manually and by electronic searches of the Chinese National Knowledge Infrastructure (1980 to 2006), English Medical Current Content (1994 to 2006), Medline (1980 to 2006) and Pub Med (1980 to 2006). The databases was searched using the following search terms: rheumatic disease, rheumatism, rheumatic complaints, osteoarthritis, spondyloarthropathy, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, Reiter syndrome, inflammatory bowel disease arthritis, rheumatoid arthritis, hyperuricemia, gout, systemic lupus erythematosus, primary Sjögren's syndrome, soft tissue rheumatism, fibromyalgia, and epidemiology, China. All of the abstracts were reviewed and relevant reports identified. The findings are presented in seven sections: rheumatic complaints; osteoarthritis (OA); ankylosing spondylitis (AS) and other forms of spondyloarthropathy (SpA); rheumatoid arthritis (RA); hyperuricemia; gout; and other rheumatic diseases. We included only population-based surveys that used the ILAR-China or COPCORD protocols, or other methods (including medical interview, physical examination and laboratory/radiographic examination) employing generally accepted diagnostic criteria, and were published in recognized journals. These reports were extracted and pooled for analysis.

Diagnostic criteria

The diagnosis of RA and systemic lupus erythematosus (SLE) was made according to the American College of Rheumatology (ACR) criteria available at the time of the study. AS was diagnosed using the New York criteria or the Modified New York criteria, and SpA was identified using the European Spondyloarthropathy Study Group criteria or the Amor criteria. OA was diagnosed on the basis of symptoms plus radiographic features, or physical findings and radiographs, or ACR classification criteria (for hand, knee, and hip OA). Hyperuricaemia was defined as serum uric acid above 7.0 mg/dl in men and above 6.0 mg/dl in women. Gout was diagnosed using the 1977 ACR criteria.

Results

More than 500 articles were identified, of which 38 surveys [3-41], involving 241,169 individuals from rural or urban areas, fulfilled the requirements for inclusion in this study (Table 1).

Table 1. List of 38 reports on common rheumatic diseases in China between 1974 and 2006

Distribution of study locations

Thirty-eight surveys were analyzed. These were conducted in 25 provinces/cities, covering an area from northeast (Heilongjiang) to southeast (Hong Kong), and from northwest (Ningxia) to east (Taiwan) of China (Figure 1).

thumbnailFigure 1. Targeted areas of the epidemiological study in China. The red circles indicate the locations of surveys of common rheumatic diseases. The yellow circles indicate the locations of hand OA surveys. 1, Heilongjiang; 2, Jilin; 3, Beijing; 4, Shandong; 5, Hebei; 6, Taiyuan; 7, Ningxia; 8, Shanghai; 9, Nanjing; 10, Taiwan; 11, Shantou; 12, Guangzhou; 13, Hong Kong.

Rheumatic complaints

The prevalence of rheumatic complaints, as reported in 13 surveys [3,9,12,15,18,19,23,28,30,41] that included 40,635 adult in seven provinces/cities, varied from 11.6% to 46.4% (Table 2). These complaints were more prevalent in women than in men, were more frequently observed in elderly than in young individuals, and were more common in the north than in the south. In the Shantou area there has been an increase in prevalence of rheumatic complaints during the past decade. The rise in prevalence with latitude previously described [42] receives support from the study findings evaluated here.

Table 2. Rheumatic complaints in general populations

Symptomatic osteoarthritis

Thirteen surveys involving 29,621 adult people from six regions reported on the prevalence of symptomatic OA [3,10,16,19,20,23,32-34,38,39], which ranged from 5.1% to 20.8% (Table 3). The lowest rate was in a urban area of Taiwan [19], and the highest rate was reported in a survey of coal miners in Handan of Hebei province [10].

Table 3. Prevalence of symptomatic osteoarthritis in China

The most common sites of OA in these reports were lumbar spine, knee joints and cervical spine. The lowest prevalence of lumbar OA (3.6%) was identified in an urban area of Taiyuan [39], and the highest rate (12.9%) in the population of coal miners [10]. Regarding the prevalence of knee OA, the lowest rate (1.3%) was identified in a Shantou school population [16], and the highest (11.1%) in a Beijing elderly urban population [34]. The lowest prevalence of cervical OA (1.4%) was identified in the coal miners [10], and the highest (4.5%) was reported from the Shantou school population [16]. Apart from these common sites of OA involvement, the prevalence rates of hip OA and elbow OA in the coal miner population were 2.0% and 1.3% [10]; the rates of hand OA among Beijing residents aged 60 years or older were 3.0% and 5.8% in men and women, respectively [33]. OA in other sites such as shoulder, elbow, hand, feet, ankle and hip were rarely observed.

Ankylosing spondylitis and the other forms of spondyloarthropathy

Seventeen surveys, including 120,451 adults from 12 provinces/cities, reported on the prevalence of AS [3,4,6,8,9,12,14,19,23,25,30,31,35,40] (Table 4). Fourteen of these 17 surveys were conducted in Han ethnic populations, and the prevalence was 0.2% to 0.54%. The other three surveys were conducted in mixed ethnic populations in Ningxia (mainly of Muslim and Han) [14], Heilongjiang (Manchu and Han) [12], and Changchun (Manchu and Han) [6], and the prevalence rates were only 0.10%, 0.09% and 0.06%, respectively. Nevertheless, a rate of 0.24% was reported from a survey conducted in 20,068 male soldiers aged 17 to 40 years and selected from 11 ethnic origins [35].

Table 4. Prevalence of spondyloarthropathy in China

The prevalence of PsA was 0.01% to 0.1% [6,25,30,31,40], reactive arthritis 0.02% [25], and undifferentiated spondyloarthropathy (uSpA) 0.64% to 1.2% [30,31,40]. No case of inflammatory bowel disease arthritis was reported.

Frequency of HLA-B27

The frequency of HLA-B27 positive status in the Han ethnic general population ranged from 3.6% to 5.7% [8,43-46]. The frequency of HLA-B27 positive status in patients with AS ranged from 90.6% to 93.6% [8,47,48]. At least eight subtypes of HLA-B27 have been identified. The most common subtypes were B2704 and B2705 [49-52]. No data on minority ethnic populations have been reported.

Family surveys of HLA-B27 positive AS revealed that about half of first-degree relatives were HLA-B27 positive, among whom the likelihood of developing AS was 50% [8,53,54].

Rheumatoid arthritis

Fifteen surveys from 10 provinces/cities, involving 94,297 adults, reported on the prevalence of RA (Table 5) [3,4,6,9,12,14,18,19,23,25,28,41]. In mainland China the prevalence ranged from 0.2% to 0.37%, and no significant difference was noted between north and south or between different ethnic groups. In the Taiwan Island [19], a higher prevalence of RA of 0.93% was reported from an urban area, but in a rural area it was 0.26%, similar to that reported from the mainland.

Table 5. Prevalence of rheumatoid arthritis in China

Hyperuricaemia and gout

During the early 1980s, the prevalence of hyperuricaemia (Table 6) was only 1.4% in males and 1.3% in females in Beijing, Shanghai, Hangzhou and Guangzhou [5]. In 1987 to 1988, however, the corresponding figures rose to 15.4% and 11.3% in Beijing [11] and 14.2% and 7.1% in Shanghai. In mainland China, the highest prevalence was reported from Qingdao [36], with rates of 32.1% in men and 21.8% in women. Nevertheless, these rates were much lower than those reported in Taiwan aborigines, at 53.8% in men and 30.7% in women [22].

Table 6. Prevalence of hyperuricemia and gout in China

Since 1992 the prevalence of primary gout has been reported in 14 surveys [3,17,19,22-24,26,28,29,36,37,41] in 11 areas involving 45,084 adults (Table 6). In mainland China, it ranged from 0.15% to 0.67% in Han Chinese. The prevalence was high in Taiwan aborigines [22], at 11.7%. In contrast, the prevalence of gout in a Taiwan rural area Han ethnic population survey [19] was only 0.16%, similar to that reported in mainland China.

The prevalence rates of primary gout in the Shantou area in 1992, 1995 and 1999 were 0.17%, 0.15% and 0.26%, respectively [29], which indicates a trend toward increased prevalence in the 1990s. Yang and coworkers [55] analyzed changes in incidence of primary gout in 21 hospitals situated throughout northern to southern China during the period from 1979 to 1993; in all cases they found a trend toward increased incidence, which was more evident in southern cities. This was in accordance with findings in Shanghai; in the latter, although no case of gout was found in the survey conducted in the 1980s, the prevalence has been more than 0.2% since 1992.

Systemic lupus erythematosus

Three surveys were carried out in 1984, 1989 and 1997 in Shanghai [7], Guangzhou [13] and Shandong [27]. The surveyed population sizes were 32,668, 25,692 and 17,044, and the obtained prevalence rates of SLE were 0.07% (70.1/100,000), 0.03% (31.1/100,000) and 0.05% (46.5/100,000), respectively.

Soft tissue rheumatism

Soft tissue rheumatism was surveyed in Shantou, Guangdong province, and Taiyuan, Shanxi province in 2005 [41]. The prevalence in Shantou was 5.7%, which is significantly higher than that in Taiyuan (2.5%). Rotator cuff tendinitis, adhesive capsulitis (frozen shoulder) and lateral epicondylitis (tennis elbow) were the most frequent soft tissue rheumatism diagnoses, with prevalence rates of 0.8%, 0.5% and 0.6%, respectively. The prevalence was significantly higher in women than in men (4.7% versus 2.6%) and exhibited an increasing trend with age, particularly in the 35 to 54 years age group. Fibromyalgia was seldom seen in both these areas; only two cases were found in Shantou (2,350 people) and one in Taiyuan (3,915 people).

Primary Sjögren's syndrome

In 1995 Zhang and coworkers [21] reported a population survey of 2,066 adults in Beijing, which indicated the prevalence of primary Sjögren's syndrome to be 0.77% by the Copenhagen classification criteria and 0.33% by the San Diego classification criteria.

Discussion

During the past two decades many studies of the epidemiology of rheumatic diseases in China have been conducted. The authors fully appreciate the difficulties in summarizing all of these reports, because most of them were not done in a uniform or systematic way. Because of these issues, only 38 surveys – including 241,169 adults from 25 provinces/cities – were pooled and analyzed. Evidently, the surveyed populations were living under different environment conditions, and age and sex distributions were diverse. Potential bias, resulting for instance from methodological problems, differences in age of the people surveyed, interobserver error, and so on, would certainly have influence the survey results. However, the key procedure in estimating disease prevalence was similar for all of these surveys, which included medical interview, physical examination and relating laboratory/radiographic examinations. Furthermore, the diagnostic criteria for the diseases considered were all generally acceptable. The major difference between studies employing the COPCORD protocol and the other studies was that the former included additional information related to the burden of disease, intervention and aetiology of disease. Most surveys included here aimed to assess prevalence rates of different rheumatic diseases, with a few including an evaluation of risk factors.

Prevalence rates of rheumatic pain reported from Australia, Bangladesh, India, Indonesia, Philippines, Thailand and Vietnam were 33%, 26.3%, 18.2%, 23.6% to 31.3%, 16.3%, 36.2% and 14.9%, respectively [56-62], indicating variation by locality, methods of survey, definition of disease categories and ethnic group. As shown in Table 2, there was a trend for the rate of positive response in the general population to a questionnaire relating to rheumatic complaints to increase with increasing latitude in locality. In Malaysian Chinese living at 5° north latitude, the prevalence of rheumatic complaints was only 13% in a 1992 survey [63]. Furthermore, in the Shantou area it was shown that after the 1980s, following growing economic development, there was a trend toward increased prevalence of rheumatic pain [42]. It is thus of importance to investigate how socioeconomic status, environmental differences, sex, age, occupation, ergonomics, bone mineral density and awareness of seeking medical care influence the prevalence of rheumatic complaints.

The prevalence of symptomatic OA varied widely with locality and population. In China the prevalence of OA ranged from 5.1% to 20.8%, with a mean of 9.1%. This was close to that reported in the other Asia Pacific countries such as Australia [56], Thailand [61], Vietnam [62], India [64] and Philippines [65] (5.5%, 11.3%, 4.1%, 5.8% and 4.1%, respectively). It is notable that in coal miners the prevalence was as high as 20.8% [10] (Table 3). Although the prevalence of hip OA was very low in Chinese as compared with UK and US Caucasians [32], the prevalence of hip OA was higher among the Chinese coal miners [10] (2.0%) than in the general population, as was found in UK miners by Lawrence [66]. This is apparently related to the heavy physical labour of the miners. In elderly Chinese males the prevalence of knee OA was comparable to that in Caucasians, but for elderly Chinese women the prevalence of knee OA was higher than in Caucasian women [34,67]. In 1995 Zeng and colleagues [68] reported that, in both clinical and epidemiological studies, the prevalence of symptomatic hand OA in Shantou, China (0.4%) was markedly lower in Chinese than in Caucasians. Reports from Hebei in 1988 [10] and Taiyuan in 2004 [39], and a cooperative Chinese-American study of hand OA (the ratio of hand OA prevalence in China to that in the USA was 0.25%, after adjustment for age) [33], further enhanced the impression that the prevalence of hand OA was indeed lower in Chinese than in Caucasians.

In China, the prevalence of AS among the Han ethnic population (0.2% to 0.54%) was close to that in Caucasians [69,70] but higher than that in Thailand (0.12%) [61]. However, among mixed ethnic populations such as Manchu and Han or Muslin and Han, the prevalence of AS (about 0.1%) was lower than that in the Han ethnic group. Although HLA-B27 was not investigated in these surveys, these findings once again suggest that genetic factors are associated with AS. Further study including HLA-B27 tests in individual minority ethnic populations is necessary to confirm these findings. uSpA was a frequently neglected form of spondylopathy. The prevalence of uSpA ranged from 0.64% to 1.21% in the Han ethnic group, even higher than that of frank AS, which challenges clinicians to improve their diagnostic awareness of uSpA.

The prevalence of RA in mainland China, ranging from 0.2% to 0.37%, was similar to that in most Asian countries [60,61,64,65,71] and South American countries [72,73] but lower than that in Caucasians [74]. In Taiwan urban and suburban areas, the prevalence of RA (0.93%) was closer to rates in Caucasians, but the prevalence of 0.26% in a Taiwan rural area was similar to that in mainland China. This might be accounted for by the fact that Taiwan urban areas were more developed than in mainland China. Apart from genetic factors, environmental and socioeconomic factors might be important risk factors for RA; this possibility awaits further study.

For some time, hyperuricaemia and gout were thought to be rare in China [5]. Since the 1980s it has become apparent that the prevalence of hyperuricaemia has exhibited a trend toward increased prevalence in both men (from 11.0% to 32.1%) and women (from 6.1% to 21.8%). Among Taiwan aborigines, the high rates of hyperuricaemia of 53.8% in men and 30.7% in women are remarkable. In mainland China, the prevalence of gout (0.15% to 0.67%) is lower than in Austronesians (Malayo-Polynesians) [75,76], Caucasians [77] and Australians [56], and slightly higher than in some other Asia countries such as Thailand, Vietnam and India (0.16%, 0.14% and 0.12%, respectively) [61,62,64]. Data from the USA showed that the overall prevalence of gout had doubled from 1969 to 1986 [78]. This trend toward a general increase indicates that living in affluent populations, and consequent changes in dietary habits and lifestyle are the main risk factors for gout. Improvement in diagnostic measures for gout may also play a role.

Prevalence of soft tissue rheumatism (2.5% to 5.7%) in China was close to that in some Asian countries such as Bangladesh (2.5%) [57] and Philippines (3.8%) [60]. Fibromyalgia was rarely observed in China, with a prevalence of 0.05 % (3/6,265), which was distinctly lower than in reports from other parts of the world [57,79]. Veerapen reported from Malaysia in 1992 [63] that the prevalence of fibromyalgia was higher among Indian than among Malay, and lowest among Chinese. This was in accordance with the situation in mainland China. Buskila and coworkers [80] claimed that fibromyalgia was associated with genetic factors. Whether the low prevalence of fibromyalgia in China has any genetic explanation awaits further study.

Many population surveys of the prevalence of SLE have been conducted in China [81]. The minimum sample size required is considered to be 30,000. In the Guangzhou and Shandong surveys the prevalence rates were 0.031% (8/25,692) and 0.053% (9/17,044), yielding a combined prevalence of 0.036% (17/46,736), which is similar to US Caucasian prevalence rates, which range from 0.0146% to 0.124% [82]. The Shanghai survey of textile factory workers revealed a higher prevalence at 0.07% (23/32,626). There was a higher proportion of women to men in the Shanghai survey (1.6:1), and so the population prevalence would have been overestimated. The factory workers might have been exposed to risk factors that are specific to that environment, such as chemical exposure.

The only survey of primary Sjögren's syndrome suggested that it was not rare in China, but many cases had previously been overlooked or misdiagnosed.

Conclusion

Rheumatic diseases are common in China. Prevalence of rheumatic symptoms increases with latitude and varies with the locality and age. The prevalence of OA was comparable with that in Western countries but exhibited variance in joint distribution; the highest rates for hip and knee OA were in coal miners. The prevalence of AS in China was similar to that in Caucasians and similarly related to HLA type. The prevalence of RA was lower than that in the developed countries except in a more developed Taiwan urban area. The prevalence of hyperuricaemia has increased since 1990. Although the prevalence of gout was lower than in the developed countries, there has been a trend toward increased prevalence in China in recent years. Fibromyalgia was rarely seen in China. China includes a vast territory with more than 50 ethnic groups. Most minority groups live in the west and northwest parts of China. Paying more attention to the epidemiology of rheumatic diseases in these areas is of great importance.

Abbreviations

APLAR = Asia Pacific League of Associations for Rheumatology; AS = ankylosing spondylitis; COPCORD = Community Oriented Program for Control of Rheumatic Diseases; ILAR = International League of Associations for Rheumatology; OA = osteoarthritis; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; SpA = spondyloarthropathy; uSpA = undifferentiated spondyloarthropathy; WHO = World Health Organization.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

QYZ participated in the design and prepared the manuscript, and took part in the ILAR-China study and WHO ILAR-APLAR COPCORD Shantou, Beijing, Taiyuan study. RC and ZYX participated in the design, and took part in the ILAR-China study and WHO ILAR-APLAR COPCORD Shantou, Beijing, Taiyuan study. SBC took part in the data collection, performed the statistical analyses and helped to prepare the manuscript. JD and RW participated in the design, helped to finalize the manuscript, were the supervisors of the WHO ILAR-APLAR COPCORD study, and took part in the ILAR-China study and WHO ILAR-APLAR COPCORD Shantou, Beijing study. SLC and NZZ directed the ILAR-China study and WHO ILAR-APLAR COPCORD study, respectively, and helped to prepare the manuscript. All authors read and approved the final manuscript.

Acknowledgements

This work was supported in part by grants from the ILAR, APLAR and Science Foundations of the Department of Education, the Department of Health of Guangdong, China.

References

  1. Muirden KD: Rheumatic diseases in China.

    J Rheumatol 1994, 21:1383-1384. PubMed Abstract OpenURL

  2. Zhang NZ: A Resume of epidemiological surveys of several main rheumatic diseases in China.

    Chin Med J 1998, 111:195-196. PubMed Abstract OpenURL

  3. Chen SL, Zeng QY: The COPCORD study in China [abstract]. In Programme and Abstracts of the 8th Asia Pacific League of Associations for Rheumatology Congress of Rheumatology. Melbourne, Australia; s182.

    21–26 April 1996

    OpenURL

  4. Beasley RP, Bennett PH, Lin CC: Low prevalence of rheumatoid arthritis in Chinese. Prevalence survey in a rural community.

    J Rheumatol 1983, (Suppl 10):11-15. OpenURL

  5. Fang Q, Chen HZ, Yu ZF, Huang BJ, Yu CH: Survey of uric acid among healthy Chinese and its relation to blood lipid.

    Chin J Intern Med (Chinese) 1983, 22:434-438. OpenURL

  6. Sun G, Xia D, Fang H: A survey of incidence of rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

    Chin J Rehabil Med (Chinese) 1988, 3:115-117. OpenURL

  7. Huang M, Chen S, Lu G, Wang W, Jiang S, Zhang L, Jin W, Yu J, Xu S, Cai Y, et al.: Epidemiological survey on systemic lupus erythematosus.

    Chin J Intern Med (Chinese) 1985, 24:451-453. OpenURL

  8. Zeng QY, Huang S, Zhou X, Li D, Chen W, Xiao Z, Li X, Xu J: Population and family survey of ankylosing spondylitis with HLA-B27 determinations.

    Chin J Intern Med (Chinese) 1987, 26:387-389. OpenURL

  9. Wigley RD, Zhang NZ, Zeng QY, Shi CS, Hu DW, Couchman K, Duff IF, Bennett PH: Rheumatic diseases in China: ILAR-China study comparing the prevalence of rheumatic symptoms in northern and southern rural populations.

    J Rheumatol 1994, 21:1484-1490. PubMed Abstract OpenURL

  10. Yang L, Guo J, Lin H: Investigation on osteoarthropathy in 1000 coal miners.

    Chin J Trad Med Traum Ort (Chinese) 1989, 5:10-13. OpenURL

  11. Li Y, Stamler J, Xiao Z, Folsom A, Tao S, Zhang H: Serum uric acid and its correlate in Chinese adult population, urban and rural, of Beijing. The PRC-USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology.

    Int J Epidemiol 1997, 26:288-296. PubMed Abstract | Publisher Full Text OpenURL

  12. Zhang F, Zhao Y, Ren X: Report on survey of rheumatic diseases in northern very cold area of China.

    Rheum Dis Integrat Chin Trad Med Moden Med (Chinese) 1992, 1:1-4. OpenURL

  13. Xu D, Li B, Chen H, Ruan Z, Zeng Y, Yang X: Epidemiological study of systemic lupus erythematosus in Guangzhou area.

    Chin J Dermatol (Chinese) 1992, 25:50-52. OpenURL

  14. Qian L, Chen J, He L, Liu R, Dong G: An epidemiological survey and analysis on the rheumatic diseases among peasants in Ningxia frigid high elevation region.

    Environ Sci (Chinese) 2001, (Suppl 22):107-109. OpenURL

  15. Xu JC, Chen R, Xu LD, Li XJ, Huang SB, Xiao ZY, Xie SH, Zhou XG, Zeng QY: An investigation of the causal factors of the higher prevalence rate of joint complain in the north than south.

    J Shantou Univ Med Coll (Chinese) 1993, 2:50-52. OpenURL

  16. Chen R, Xu LD, Xu JC, Li XJ, Zhou XG, Xiao ZY, Huang SB, Xie SH: Population study of symptomatic osteoarthritis.

    J Shantou Univ Med Coll (Chinese) 1993, 2:54-56. OpenURL

  17. Zeng QY, Zhou XG, Xiao ZY, Huang SB, Xie SH, Xu LD, Chen R, Xu JC, Li XJ: BMD of distal radius and gout in the population of middle schools in Chenghai downtown.

    J Shantou Univ Med Coll (Chinese) 1993, 6:46-49. OpenURL

  18. Lau E, Symmons D, Bankhead C, Macgregor A, Donnan S, Silman A: Low prevalence of rheumatoid arthritis in the urbanized Chinese of Hong Kong.

    J Rheumatol 1993, 20:1133-1137. PubMed Abstract OpenURL

  19. Chou CT, Pei L, Chang DM, Lee CF, Schumacher HR, Liang MH: Prevalence of rheumatic diseases in Taiwan: a population study of urban, suburban, rural differences.

    J Rheumatol 1994, 21:302-306. PubMed Abstract OpenURL

  20. Zhang N, Shi Q, Zhang X, Sha L, Wang Y, Zhao S, Lu S, Yu G, Qu H: An epidemiological study of knee osteoarthritis.

    Chin J Intern Med (Chinese) 1995, 34:84-87. OpenURL

  21. Zhang NZ, Shi CS, Yao QP, Pan GX, Wang LL, Wen ZX, Li XC, Dong Y: Prevalence of primary Sjögren's syndrome in China.

    J Rheumatol 1995, 22:659-661. PubMed Abstract OpenURL

  22. Chou CT, Lai JS: The epidemiology of hyperuricemia and gout in Taiwan aborigines.

    Br J Rheumatol 1998, 37:258-262. PubMed Abstract | Publisher Full Text OpenURL

  23. Zeng QY, Chen R, Xiao ZY, Liu Y, Xu J, Wigkey RD: Shantou COPCORD study: stage I.

    APLAR Bull 1995, 13:74-76. OpenURL

  24. Chang H, Pan W, Yeh W, Tsai K: Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993–1996).

    J Rheumatol 2001, 28:1640-1646. PubMed Abstract OpenURL

  25. Zhang H, Liu Z, Su H, Zhou H, Xun Y, Jiang X: Epidemiological studies on rheumatoid arthritis and ankylosing spondylitis in rural area of Shandong province.

    Chin J Rheumatol (Chinese) 1998, 2:85-87. OpenURL

  26. Chen S, Du H, Wang Y, Xu L: The epidemiology study of hyperuricemia and gout in a community population of Huangpu District in Shanghai.

    Chin Med J 1998, 111:228-230. PubMed Abstract OpenURL

  27. Jiang B, Zhang Y, Xu X, Mei H, Wang G, Ding F, Ding Z: A prevalence study of rheumatic diseases in eastern coastline of Shandong province.

    Acta Acad Med Shandong (Chinese) 2001, 39:210-211. OpenURL

  28. Dai S, Han X, Zhao D, Shi Y, Liu Y, Meng J: Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study.

    J Rheumatol 2003, 30:2245-2251. PubMed Abstract OpenURL

  29. Zeng QY, Wang Q, Chen R, Xiao Z, Huang S, Xu J: Primary gout in Shantou: a clinical and epidemiological study.

    Chin Med J 2003, 116:66-69. PubMed Abstract | Publisher Full Text OpenURL

  30. Chen R, Wang Q, Lin Q, Wu X, Xu J, Xie S, Zeng QY: Epidemiological study of seronegative spondyloarthropathies.

    Chin J Rheumatol (Chinese) 2000, 4:240-241. OpenURL

  31. Chen R, Du L, Lin Q, Chen S, Lin L, Xu J, Xie S: Epidemiological study of seronegative spondyloarthropathies in Beijing area.

    Chin J Prim Med Pharm (Chinese) 2002, 9:593-594. OpenURL

  32. Nevitt MC, Xu L, Zhang Y, Lui L, Yu W, Lane NE, Qin M, Hochberg MC, Cummings SR, Felson DT: Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with Whites in the United States.

    Arthritis Rheum 2002, 46:1773-1779. PubMed Abstract | Publisher Full Text OpenURL

  33. Zhang Y, Xu L, Nevitt MC, Niu J, Goggins JP, Aliabadi P, Yu W, Lui LY, Felson DT: Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study.

    Arthritis Rheum 2003, 48:1034-1040. PubMed Abstract | Publisher Full Text OpenURL

  34. Zhang Y, Xu L, Nevitt MC, Aliabadi P, Yu W, Qin M, Lui LY, Felson DT: Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the Beijing Osteoarthritis Study.

    Arthritis Rheum 2001, 44:2065-2071. PubMed Abstract | Publisher Full Text OpenURL

  35. Cao T, Huang H, Duan Y, Ji Y, Chen L, Dong D, Li H, Wang B, Zhang G: Epidemiological study of ankylosing spondylitis of the men of military officers and soldiers in Northeast Military Region.

    Chin J Rheumatol (Chinese) 2000, 4:307-308. OpenURL

  36. Nan H, Qiao Q, Dong Y, Gao W, Tang B, Qian R, Tuomilehto J: The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China.

    J Rheumatol 2006, 33:1346-1350. PubMed Abstract | Publisher Full Text OpenURL

  37. Shao J, Mo B, Yu R, Li Z, Liu H, Xu Y: Epidemiological study on hyperuricemia and gout in community of Nanjing.

    Chin J Dis Control Prev (Chinese) 2003, 7:305-308. OpenURL

  38. Du H, Chen S, Bao C, Wang X, Lu Y, Gu Y, Xu J, Chai W, Chen J, Nakamura H, et al.: Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China.

    Rheumatol Int 2005, 25:585-590. PubMed Abstract | Publisher Full Text OpenURL

  39. Zang C, Zeng QY, Li X, Dong H, Zhang A: Epidemiological study of osteoarthritis in Taiyuan.

    Shanxi Med J (Chinese) 2006, 35:767-770. OpenURL

  40. Dong H, Zang C, Zhang A, Zheng J: Epidemiological study of seronegative spondyloarthropathies in Taiyuan.

    Chin Remedies Clinics (Chinese) 2006, 6:262-265. OpenURL

  41. Zang CH, Zeng QY, Li X, Dong H, Zhang A: Epidemiological study of rheumatic diseases in Taiyuan area.

    Chin Remd Clin (Chinese) 2007, 7:597-602. OpenURL

  42. Zeng QY, Darmawan J, Xiao ZY, Chen SB, Chen R, Lin K, Wigley R, Chen SL, Zhang NZ: Risk factors associated with rheumatic complaints: a WHO-ILAR COPCORD study in Shantou, southeast China.

    J Rheumatol 2005, 32:920-927. PubMed Abstract | Publisher Full Text OpenURL

  43. Zhang G, Yang Y, Feng Z, Zhang Y, Feng M, Ji Y, Lu Q, Ma J, Ji Y, Mao X, et al.: Report of HLA distribution of Chinese Bone Marrow Bank (Shanghai).

    Chin J Organ Transplant (Chinese) 2001, 22:179-185. OpenURL

  44. Song Y, Zhu C, Lv H, Rong Z, Nie X, Wang M, Liu Y: HLA-A, B, DRB1 gene distribution of Shandong Han ethnic population bone marrow bank.

    Chin J Blood Transfus (Chinese) 2005, 18:327-329. OpenURL

  45. Deng Y, Yang G, Wu D, Hu S, Li S, Zhu J, Zhu B, Liu Y: HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing.

    Chin J Med Genet (Chinese) 2006, 23:103-106. OpenURL

  46. Wu G, Deng Z, Gao S, Cheng L, Jin S, Zhou D, Li Z, Zhou H, Zhang X, Wei T, et al.: Study of HLA polymorphism in the 6965 Han bone marrow registry donors.

    Chin J Hematol (Chinese) 2004, 25:473-477. OpenURL

  47. Dai Q, Huang Y: Significance of HLA-B27 determination in the diagnosis of ankylosing spondylitis.

    Occupation Health (Chinese) 2006, 22:2005-2006. OpenURL

  48. Liu H: HLA-B27 in ankylosing spondylitis patients in Yuxi area.

    Shandong Med J (Chinese) 2006, 46:69-70. OpenURL

  49. Lin J, Lv H, Chen Z, Jiang D, Wang S, Feng C: Ankylosing spondylitis and HLA-B27 subtypes: a disease related research in Chinese Han nationality.

    J Beijing Med Univ (Chinese) 1994, 26:323-326. OpenURL

  50. Lin J, Lv H, Feng C: Ankylosing spondylitis and heterogenity of HLA-B27 in Chinese.

    Chin J Surg (Chinese) 1996, 34:333-335. OpenURL

  51. Jiang L, Fan L, Yang J, Yao F, Zhou J, Xu R, Gao P: Study on ankylosing spondylitis and HLA-B27 alleles.

    Chin J Immunol (Chinese) 1997, 13:345-348. OpenURL

  52. Yang G, Deng Y, Yan C, Wu D, Hu S, Zhu B, Li S, Zhang X, Liu Y: Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese.

    Acta Acad Med Sin (Chinese) 2006, 28:240-243. OpenURL

  53. Huang F, Zhao H, Shi G: Family surveys of 5 cases of spondyloarthropathies.

    Chin J Intern Med (Chinese) 1994, 33:44-45. OpenURL

  54. Cai Q, Han X, Chen R, Yang B, Zhao F: Family aggregation of ankylosing spondylitis.

    Chin J Rheumatol (Chinese) 2003, 7:668-672. OpenURL

  55. Yang X, Tang F, Yin P: The trend of proportion among inpatients with gout in 21 hospitals during the past 15 years.

    Chin J Epidemiol (Chinese) 1996, 17:10-12. OpenURL

  56. Minaur N, Sawyers S, Parker J, Darmawan J: Rheumatic disease in an Australian Aboriginal community in North Queensland, Australia. A WHO-ILAR COPCORD survey.

    J Rheumatol 2004, 31:965-972. PubMed Abstract | Publisher Full Text OpenURL

  57. Haq SA, Darmawan J, Islam MN, Uddin MZ, Das BB, Rahman F, Chowdhury MAJ, Alam MN, Mahmud TAK, Chowdhury MR, et al.: Prevalence of rheumatic diseases and associated outcomes in rural and urban communities in Bangladesh: a COPCORD study.

    J Rheumatol 2005, 32:348-353. PubMed Abstract | Publisher Full Text OpenURL

  58. Chopra A, Saluja M, Patil J, Tandale HS: Pain and disability, perceptions and beliefs of a rural Indian population: a WHO-ILAR COPCORD study.

    J Rheumatol 2002, 29:614-621. PubMed Abstract | Publisher Full Text OpenURL

  59. Darmawan J, Valkenburg HA, Muirden KD, Wigley RD: Epidemiology of rheumatic diseases in rural and urban populations in Indonesia.

    Ann Rheum Dis 1992, 51:525-528. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  60. Dans LF, Tankeh-Torres S, Amante CM, Penserga EG: The prevalence of rheumatic diseases in a Filipino urban population: a WHO-ILAR COPCORD study.

    J Rheumatol 1997, 24:1814-1819. PubMed Abstract OpenURL

  61. Chaiamnuay P, Darmawan J, Muirden KD, Assawatanabodee P: Epidemiology of Rheumatic disease in rural Thailand: a WHO-ILAR COPCORD study.

    J Rheumatol 1998, 25:1382-1387. PubMed Abstract OpenURL

  62. Minh Hoa TT, Darmawan J, Chen SL, Van Hung N, Thi Nhi C, Ngoc An T: Prevalence of the rheumatic diseases in urban Vietnam: a WHO-ILAR COPCORD study.

    J Rheumatol 2003, 30:2252-2256. PubMed Abstract OpenURL

  63. Veerapen K: Epidemiology of rheumatic disease in Malaysia.

    APLAR Rheumatology. Edited by Nasution R. London, UK: Churchill Livingstone 1992, 397-399. OpenURL

  64. Chopra A, Patil J, Billempelly V, Relwani J, Tandle HS: Prevalence of rheumatic diseases in a rural population in western India: a WHO-ILAR COPCORD study.

    J Assoc Physicians India 2001, 49:240-246. PubMed Abstract OpenURL

  65. Wigley R, Manahan L, Muirden KD, Caragay R, Pinfold B, Couchman KG, Valkenburg HA: Rheumatic disease in a Philippine village. II: a WHO-ILAR- APLAR COPCORD study, phases II and III.

    Rheumatol Int 1991, 11:157-161. PubMed Abstract | Publisher Full Text OpenURL

  66. Lawrence JS: Occupational aspects of the rheumatic diseases. In Rheumatism in Populations. Edited by Lawrence JS. London, UK: William Heinemann Medical Books Ltd; 1977:466-493. OpenURL

  67. Felson DT, Zhang Y: An update on the epidemiology of knee and hip osteoarthritis with a view to prevention.

    Arthritis Rheum 1998, 41:1343-1355. PubMed Abstract | Publisher Full Text OpenURL

  68. Zeng QY, Huang S, Xiao Z, Chen S, Liu X, Zhou X: Osteoarthritis: clinical and epidemiological investigation.

    Chin J Intern Med (Chinese) 1995, 34:88-90. OpenURL

  69. Carter ET, McKenna CH, Brian DD, Kurland LT: Epidemiology of ankylosing spondylitis in Rochester, Minnesota: 1935–1973.

    Arthritis Rheum 1979, 22:365-370. PubMed Abstract | Publisher Full Text OpenURL

  70. Gran JT, Husby G, Hordvik M: Prevalence of ankylosing spondylitis in males and females in a young middle aged population of Tromso, Northern Norway.

    Ann Rheum Dis 1985, 44:359-367. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  71. Darmawan J, Muirden KD, Valkenburg HA, Wigley RD: The epidemiology of rheumatoid arthritis in Indonesia.

    Br J Rheumatol 1993, 32:537-540. PubMed Abstract | Publisher Full Text OpenURL

  72. Senna ER, De Barros ALP, Silva EO, Costa IF, Pereira LVB, Ciconelli RM, Ferraz MB: Prevalence of rheumatic diseases in Brazil: a study using the COPCORD approach.

    J Rheumatol 2004, 31:594-597. PubMed Abstract | Publisher Full Text OpenURL

  73. Cardiel MH, Rojas-Serrano J: Community based study to estimate prevalence, burden of illness and help seeking behavior in rheumatic diseases in Mexico City. a COPCORD study.

    Clin Exp Rheumatol 2002, 20:617-624. PubMed Abstract OpenURL

  74. Silman A, Hochberg MC, (editors): Epidemiology of the Rheumatic Diseases. Oxford, UK: Oxford University Press; 1993:16-20. OpenURL

  75. Darmawan J, Valkenburg HA, Muirden KD, Wigley RD: The epidemiology of gout and hyperuricemia in a rural population of Java.

    J Rheumatol 1992, 19:1595-1599. PubMed Abstract OpenURL

  76. Darmawan J, Lutalo SK: Gout and hyperuricaemia.

    Baillieres Clin Rheumatol 1995, 9:83-94. PubMed Abstract | Publisher Full Text OpenURL

  77. Harris CM, Lloyd DCEF, Lewis J: The prevalence and prophylaxis of gout in England.

    J Clin Epidemiol 1995, 48:1153-1158. PubMed Abstract | Publisher Full Text OpenURL

  78. Lawrence RC, Hochberg MC, Kelsey JL, Mcduffie FC, Medsger TA, Felts WR, Shulman LE: Estimates of the prevalence of selected arthritic and musculoskeletal diseases in the United States.

    J Rheumatol 1989, 16:427-441. PubMed Abstract OpenURL

  79. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L: The prevalence and characteristics of fibromyalgia in the general population.

    Arthritis Rheum 1995, 38:19-28. PubMed Abstract | Publisher Full Text OpenURL

  80. Buskila D, Sarzi-Puttini P: Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.

    Arthritis Res Ther 2006, 8:218. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  81. Xu KF: Systemic lupus erythematosus in Chinese populations.

    APLAR Bull 1995, 13:70-74. OpenURL

  82. Petri M: Epidemiology of systemic lupus erythematosus.

    Best Pract Res Clin Rheumatol 2002, 16:847-858. PubMed Abstract | Publisher Full Text OpenURL