Table 3

CP-690550 serum levels (ng/ml)

Dose (mg/kg/d)

Mouse study 1a

Mouse study 2b

Rat study


15

70 ± 17

37 ± 5

259 ± 41

5

27 ± 6

17 ± 2

124 ± 16

1.5

6 ± 1

< LLOQ

24 ± 5


Data are mean ± standard error of the mean. All samples were collected at the termination of the study. n = 10 for all groups. LLOQ, lower limit of quantification.

aLLOQ = 5 ng/ml (Pfizer study).

bLLOQ = 10 ng/ml (Boulder BioPath study).

Milici et al. Arthritis Research & Therapy 2008 10:R14   doi:10.1186/ar2365

Open Data