Table 3 |
|||
|
CP-690550 serum levels (ng/ml) |
|||
| Dose (mg/kg/d) |
Mouse study 1a |
Mouse study 2b |
Rat study |
|
|
|||
| 15 |
70 ± 17 |
37 ± 5 |
259 ± 41 |
| 5 |
27 ± 6 |
17 ± 2 |
124 ± 16 |
| 1.5 |
6 ± 1 |
< LLOQ |
24 ± 5 |
|
|
|||
|
Data are mean ± standard error of the mean. All samples were collected at the termination of the study. n = 10 for all groups. LLOQ, lower limit of quantification. aLLOQ = 5 ng/ml (Pfizer study). bLLOQ = 10 ng/ml (Boulder BioPath study). |
|||
|
Milici et al. Arthritis Research & Therapy 2008 10:R14 doi:10.1186/ar2365 |
|||
