Histological evaluation of damage to foot pad in rat adjuvant-induced arthritis (AA) model. Representative sections from vehicle (a) and 15 mg/kg/day CP-690550 (b) treated rats on day 24. In the vehicle treated animal there was significant inflammation (asterisk) and destruction of the metatarsal bone (arrow) and joint spaces (arrowhead). In contrast, there was no inflammation and the metatarsal joint spaces appeared normal in the CP-690550 treated animal.
Milici et al. Arthritis Research & Therapy 2008 10:R14 doi:10.1186/ar2365