Figure 3.

Histological evaluation of damage to murine knees. Histological sections of knee samples from murine collagen-induced arthritis study 1 were graded as described in Table 1. CP-690550 produced a dose-dependent inhibition of knee damage that reached statistical significance (p < 0.0001) at the 15 mg/kg/day dose relative to vehicle.

Milici et al. Arthritis Research & Therapy 2008 10:R14   doi:10.1186/ar2365
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