Method for rat strenuous running. (a) Rodent treadmill machine designed to compulsively make rats run. (b) Protocol for running exercise. Rats were forced to run 30 km in 6 weeks. For the hyaluronan group, the injection was performed initially at 5 days, followed by every 7 days (arrows).
Tang et al. Arthritis Research & Therapy 2008 10:R13 doi:10.1186/ar2363