Table 2

Sensitivity, specificity and positive predictive value of anti-MCV and anti-CCP for clinical diagnosis of RA in early arthritis patients

Antibody

Sensitivity (%; 95% CI)

Specificity (%; 95% CI)

PPV (%)

Anti-CCP2 level ≥ 25 U/ml

55.3 (46.1 to 64.2)

92.1 (77.5 to 97.9)

95.8

Anti-MCV level ≥ 20 U/ml

59.3 (50.1 to 67.9)

92.3 (78.0 to 97.9)

96.1

Shown are the sensitivity, specificity and positive predictive value (PPV) of anti-mutated citrullinated vimentin (anti-MCV) and anti-second-generation cyclic citrullinated peptide (anti-CCP2) for the clinical diagnosis of rheumatoid arthritis (RA) in early arthritis, using cut off values recommended by the manufacturers of the tests. A total of 162 patient with early arthritis were included in the analysis. CI, confidence interval.

Ursum et al. Arthritis Research & Therapy 2008 10:R12   doi:10.1186/ar2362