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Studies examining the effect of knee injury and/or alignment on the relationship between physical activity and risk for developing knee OA |
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| Author (year) |
Study design/participants |
Measure(s) of OA |
Measure(s) of physical activity |
Results: effect of alignment/injury |
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| Studies investigating self-reported symptomatic OA |
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| Sutton et al. (2001) [20] |
Retrospective case-control study/1,080 healthy participants |
Self-reported, symptomatic |
Self-reported; parameters not specified |
Past history of knee injury was associated with increased risk for knee OA (OR 8.0, 95% CI 2.0 to 32.0) |
| Kujala et al. (1999) [19] |
11-year cohort study/269 runners and 188 control individuals |
Self-reported, symptomatic |
Self-reported; MET index (intensity, duration and frequency); level of breathlessness |
Runners reported knee OA more often than control individuals (OR 1.79, 95% CI 1.10 to 3.54 [P = 0.025]) |
| The age-adjusted OR for having had knee ligament or meniscus injury was 1.62 (95% CI 0.99 to 2.65 [P = 0.055]) in runners compared with control individuals |
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| Studies investigating self-reported physician diagnosed OA |
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| Kujala et al. (1999) [19] |
11-year cohort study/269 runners and 188 control individuals |
Self-reported, physician diagnosed |
Self-reported; MET index (intensity, duration and frequency); level of breathlessness |
Runners reported knee OA more often than control individuals (OR 1.79, 95% CI 1.10 to 3.54 [P = 0.025]). |
| The age-adjusted OR for having had knee ligament or meniscus injury was 1.62 (95% CI 0.99 to 2.65 [P = 0.055]) in runners compared with control individuals |
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| Radiographic studies investigating structural OA |
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| Kujala et al. (1995) [15] |
Retrospective cohort study/117 male former top-level athletes |
Radiographic, structural; clinical |
Self-reported; parameters not-specified |
The risk of knee OA was increased in those with previous knee injuries (OR 4.73, 95% CI 1.32 to 17.0) |
| McDermott and Freyne (1983) [16] |
Cross-sectional study/20 middle/long-distance runners |
Radiographic, structural; clinical examination and arthroscopy |
Self-reported; years of training/competition, training mileage |
OA was reported in 6 of the 20 runners; athletes with degenerative changes had been running for a greater number of years (P < 0.05) |
| Participants with degenerative changes had greater incidence of genu varum and had experienced more knee injuries (P < 0.05) |
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BMI, body mass index; CI, confidence interval; MET, metabolic equivalent; OA, osteoarthritis; OR, odds ratio. | ||||
Urquhart et al. Arthritis Research & Therapy 2008 10:203 doi:10.1186/ar2343 |
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