Table 2 |
||||
|
Studies examining the effect of BMI on the relationship between physical activity and risk for developing knee OA |
||||
| Author (year) |
Study design/participants |
Measure(s) of OA |
Measure(s) of physical activity |
Results: effect of BMI |
|
|
||||
| Studies investigating self-reported symptomatic OA |
||||
| Felson et al. (2007) [11] |
9-year longitudinal cohort study/1,279 participants from the Framingham Offspring
cohort |
Self-reported, symptomatic |
Self-reported; frequency, type, intensity |
Overall results are presented in Table 1 |
| Among persons with BMI above the median, there was no relationship between the risk
for knee OA and the following: walking (≥6 miles/week; OR 0.84, 95% CI 0.37 to 1.92);
working up a sweat (≥3 times/week; OR 1.04, 95% CI 0.55 to 1.96); and activity level
compared with peers (more active; OR 0.63, 95% CI 0.35 to 1.16) |
||||
| Studies investigating self-reported physician diagnosed OA |
||||
| Hootman et al. (2003) [10] |
12.8-year cohort study/5,284 participants from the Cooper Clinic |
Self-reported, physician diagnosed |
Self-reported; joint stress physical activity score (intensity, frequency, duration
and type) |
Increasing levels of the joint stress physical activity score were not associated
with an increased risk for hip/knee OA for both men (high level; OR 1.07, 95% CI 0.47
to 2.42) and women (high level: OR 1.31, 95% CI 0.92 to 1.87) |
| BMI did not modify the relationship between moderate physical activity and risk for
knee OA for both men (OR 1.07, 95% CI 1.03 to 1.11) and women (OR 1.12, 95% CI 1.06
to 1.19) |
||||
| Radiographic studies investigating structural OA |
||||
| Felson et al. (2007) [11] |
9-year longitudinal cohort study/1,279 participants from the Framingham Offspring
cohort |
Radiographic, structural |
Self-reported; frequency, type, intensity |
Overall results presented in Table 1 |
| Among persons with BMI above the median, there was no relationship between the risk
of radiographic knee OA and the following: walking (≥6 miles/week; OR 0.95, 95% CI
0.55 to 1.62); working up a sweat (≥3 times/week; OR 1.22, 95% CI 0.67 to 2.21); and
activity level compared with peers (more active; OR 0.82, 95% CI 0.48 to 1.40) |
||||
| McAlindon et al. (1999) [14] |
8-year longitudinal cohort study/473 participants from the Framingham Heart Study
cohort |
Radiographic, structural |
Self-reported: Framingham physical activity index; activity type, duration |
The number of hours per day of heavy physical activity was associated with risk for
knee OA (≥4 hours heavy activity/day compared with no heavy activity; OR 7.0, 95%
CI 2.4 to 20 [P = 0.0002]) |
| Risk for OA was greatest among individuals in the upper tertile of BMI (≥3 hours/day
of heavy physical activity; OR 13.0, 95% CI 3.3 to 51) |
||||
| Kujala et al. (1995) [15] |
Retrospective cohort study/117 male former top-level athletes |
Radiographic, structural |
Self-reported; parameters not-specified |
Risk for knee OA was increased in athletes with a higher BMI at age 20 years (OR 1.76/unit
increase, 95% CI 1.26 to 2.45) |
|
|
||||
|
BMI, body mass index; CI, confidence interval; OA, osteoarthritis; OR, odds ratio. |
||||
|
Urquhart et al. Arthritis Research & Therapy 2008 10:203 doi:10.1186/ar2343 |
||||