Table 1

Tumor necrosis factor (TNF) expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus

Model [Reference]

TNF expression

Effects of recombinant TNF

Effects of TNF blockade/deficiency


NZB [12]

Normal

NA

Severe lupus in TNF-/- animals

NZB/W [9,10]

Low

High dose: late onset (if given early), prolonged survival

NA

[15]

High in nephritis

Low dose (late): increased renal inflammation

MRL/lpr [13,14]

High

NA

Improved arthritis, pneumonitis

Moth-eaten [18]

High

NA

Improved skin, arthritis, pneumonitis

C3H.SW [19]

High

NA

Less severe nephritis, leukocytopenia


NA, not assessed.

Aringer and Smolen Arthritis Research & Therapy 2008 10:202   doi:10.1186/ar2341