Table 1 |
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Tumor necrosis factor (TNF) expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus |
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|
Model [Reference] |
TNF expression |
Effects of recombinant TNF |
Effects of TNF blockade/deficiency |
|
|
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|
NZB [12] |
Normal |
NA |
Severe lupus in TNF-/- animals |
|
NZB/W [9,10] |
Low |
High dose: late onset (if given early), prolonged survival |
NA |
|
[15] |
High in nephritis |
Low dose (late): increased renal inflammation |
|
|
MRL/lpr [13,14] |
High |
NA |
Improved arthritis, pneumonitis |
|
Moth-eaten [18] |
High |
NA |
Improved skin, arthritis, pneumonitis |
|
C3H.SW [19] |
High |
NA |
Less severe nephritis, leukocytopenia |
|
|
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|
NA, not assessed. |
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Aringer and Smolen Arthritis Research & Therapy 2008 10:202 doi:10.1186/ar2341 |
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