Heterogeneous JunB expression within lesional psoriatic skin. Immune reactivity of a monoclonal antibody against JunB within a psoriatic lesion. (a) Distinct anti JunB reactivity of a parakeratotic lesion. JunB expression is observed throughout all epidermal layers (left side, arrow), whereas it is reduced on the right side of the lesion (see arrow). (b) A different area of the same lesion. A virtual absence of nuclear reactivity is seen in basal keratinocytes, whereas strong nuclear activity is detected in the upper suprabasal epidermal layers ((a) and (b) arrows).
Zenz et al. Arthritis Research & Therapy 2008 10:201 doi:10.1186/ar2338